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The liver is one of the most frequently injured abdominal organs during motor vehicle crashes. Realistic numerical assessments of liver injury risk for the entire occupant population require incorporating inter-subject variations into numerical models. The main objective of this study was to quantify the shape variations of human liver in a seated posture and the statistical distributions of its material properties. Statistical shape analysis was applied to construct shape models of the livers of 15 adult human subjects, recorded in a typical seated (occupant) posture. The principal component analysis was then utilized to obtain the modes of variation, the mean model, and 95% statistical boundary shape models. In addition, a total of 52 tensile tests were performed on the parenchyma of three fresh human livers at four loading rates (0.01, 0.1, 1, and 10 s−1) to characterize the rate-dependent and failure properties of the human liver.

The THOR-NT dummy has been developed and continuously improved by NHTSA to provide automotive manufacturers an advanced tool that can be used to assess the injury risk of vehicle occupants in crash tests. With the recent improvements of finite element (FE) technology and the increase of computational power, a validated FE model of THOR may provide an efficient tool for the design optimization of vehicles and their restraint systems. The main goal of this study was to improve biofidelity of a head-neck FE model of THOR-NT dummy. A three-dimensional FE model of the head and neck was developed in LS-Dyna based on the drawings of the THOR dummy. The material properties of deformable parts and the joints properties between rigid parts were assigned initially based on data found in the literature, and then calibrated using optimization techniques.