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A general concept of designing an autonomous water system for interplanetary spaceships is proposed. The system features a high reliability resulting from the mutual complement and partial or complete backup of the elements. The system consists of three interconnected subsystems: water-supplies, regenerative physicochemical and biological ones, each providing the crew with water during different stages of a long-term space mission. The system is expected to be a further step in developing a closed-cycle, autonomous, biotechnologies life-support system.