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With astronauts and cosmonauts spending longer periods in space, we must understand and anticipate the effects of the environment on those who live and work in space and on their progeny. Since current launch vehicles restrict payload to low volumes and low masses, we must work within these design restrictions. Two biological experiments, one involving female newts and the other involving the eggs of a small fresh-water fish called revulines, are to be carried aboard the Japanese space flyer unit (SFU) in 1994. The experiment system, named BIO, is implemented on Special Payload Unit (SPLU) of SFU. Experiment are conducted with a service provided for SPLU. BIO consists of two experiment units, a controller, and a power supply. Each experiments, contains an aqua chamber to hold the live specimens. The temperature and gas in the chamber are maintained by a thermo exchanger and gas exchanger.