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Commercial airline cockpit crews flying transoceanic routes were tested repeatedly with a battery of cognitive tests implemented on a lap-top microcomputer. Testing was conducted before departure and during the early, middle, and late periods in flight on the outbound leg of four flight pairings. The same tests were administered on the return leg(s) of each flight pairing but, just prior to final administration of the tests, six minutes of moderate resistance exercise was undertaken by the Captain and one other pilot (either the First or Second Officer). The remaining officer substituted a walk around the aircraft cabin for exercise and served as a control. The same Flight Captain was available for testing on all flights (N = 22), but due to scheduling requirements, the same First and Second Officers were available for 4-8 flights each. Comparisons were made between the two exercise conditions over all test sessions, but no statistical relationships were found.