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PEMFC systems are gaining increased importance as clean and efficient energy sources for electric vehicles. Research and development at Degussa-Huels AG is focused on catalyst systems for mobile PEMFC applications, particularly membrane-electrode-assemblies (MEAs) for PEMFC stacks and catalysts for fuel processing, i.e. generation and purification of hydrogen [1,2,3]. Results of steady state and transient measurements performed with advanced catalysts for preferential oxidation of CO (PrOx) and new MEAs based on CO-tolerant electrocatalysts are presented in this paper.