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This paper deals with a man-made Gas Atmosphere (MMGA) Simulation Model developed and software presented for the Russian Segment of the International Space Station (ISS). The simulation Model (SM) is intended for analysis of the MMGA parameter nonstationary values in isothermal and non-isothermal conditions under a variable number of crew taking into account the intensities of the crew activity. The person's structure of the SM, basic assumptions, taken for modeling and formalized descriptions of SM separate modules. Formalized descriptions by the Segment's Pressurized Modules are based on using the nonlinear equations of mass/energy balance for the controlling volume, taking into account all main sources and sinks of the environment separate components, which are a crew, Integrated Regenerative Life Support System (IRLSS) separate subsystems, ISS on-board systems.