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This paper deals with the Complex Simulation Model of Human Organism (HOCSM) intended for various problems' solutions of the Manned Space Objects Ecological and Technical System (ETS) development. Among the fundamental problems of the ETS development requiring the HOCSM adaptation are: (a) forming the mass and energetic loads of spacecraft crew for the simulation of the ETS functions; (b) the investigation of environment effects on a human organism and its responses; (c) the analysis of interactions between the crew and the individual life support system or its functional blocks; (d) the decisions of design problems for development of the anti exposure and space suits. The HOCSM, under consideration, is based on the general theory of functional systems and includes formalistic descriptions of following human organism functional systems: a cardiovascular systems, an external respiration system, a thermoregulation system and a water-salt balance system.