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The paper proposes a performance prediction method at design and off design values of mass rate and rotational speed for a low pressure ratio (2.2:1) centrifugal compressor capable of rotating at speeds up to 90000 r.p.m. The procedure employed consists of combining selected losses obtained from semi-empirical equations to construct an overall picture of efficiency of the compression process. The estimated performance of a radial centrifugal compressor with splitter blades was compared with experimental results covering wide range of the performance map, the achieved level of agreement was approximately within 4% from measurements. It should be mentioned however that the proposed method does not describe the internal aerodynamic effects occuring, it does however isolate some important variables and then relate them to the total pressure loss across the stage.