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The advent of flexible fuels has created a need in the automotive industry for materials that perform in the exceptionally aggressive environment of alternate fuels. This Paper outlines an extensive alternate fuel testing study by Hoechst Celanese of five different crystalline engineering thermoplastics including Acetal Copolymer, Nylon 6/6, Polyphenylene Sulfide, PBT Polyester, and Liquid Crystal Polymer. These five base resins were used in unfilled, glass fiber reinforced, impact modified, glass/mineral reinforced, and long–glass fiber reinforced grades. All the materials were tested in Fuel C, Auto–Oxidized (sour gas), and Aggressive Fuel with M25, M50, M85 at 60°C and 121°C. The driving force motivating Hoechst Celanese to evaluate their crystalline engineering thermoplastics is the automotive industries shift towards alternate fuels and higher operating temperatures.