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A robust nonlinear meshfree computer-aided-engineering (CAE) analysis algorithm based on the Reproducing Kernel Particle Method (RKPM) is employed for simulating the installation and sealing performance of a truck-based radiator hose/fitting/clamp system assembly. The formulation of the present nonlinear meshfree CAE simulation comprises the geometric and material nonlinearities, a Lagrangian material based reproducing kernel shape function, a pressure projection method for nearly incompressible rubber hose material, and a direct transformation method for frictional contact boundary conditions. This simulation, which defines a radiator hose/fitting operating process series as insertion, clamping, pressurization and pull-off, provides a parametric investigation on the effect of clamping depth, clamping width, clamping location, and fluid pressure load on the hose-fitting contact seal width, contact pressure distribution, and the maximum pull-off force properties.