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This paper explores a framework for simulating the lifecycle costs of an automotive component for alternative material systems. The front fender for a midsize sedan is chosen as a case study. The material systems under consideration include the following: stamped steel, stamped aluminum, compression molded SMC, injection molded thermoplastic, and reinforced reaction injection molded polyurethane (RRIM PUR). The lifecycle for the fender is defined to include manufacturing, operation, and post-use. Using a technique called Technical Cost Modeling, manufacturing costs including fabrication, assembly, and priming are simulated for a range of production volumes. Operation costs are calculated in two areas: fuel consumption and repair. Component weight is examined as it influences fuel consumption (and therefore cost) for varying scenarios of vehicle life and annual mileage. Repair costs are assessed for different collision speeds and directions.