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The use of jet-fuel, de-icing fluids, lubricants, hydraulics, engine oil and other fluids, are associated with single repeated/accidental or chronic exposure (s) to ground staff, flight-deck and cabin crew and passengers. These fluids can become airborne in vapor or aerosol phases, and are known to contain neurotoxicants, carcinogens, irritants and other toxic ingredients. Exposures (single or repeated) to these toxic materials are not rare events and some typical failures/working conditions include mechanical failures, seal leaks, and operational procedures, such as take off while fumes detected, pack burn outs. A method for calculation of exposure dose is proposed. The additional impact of exposure to toxicants in conditions of lowered pressure (and reduced oxygen level), other potentiation factors are still largely unknown, but are not presumed to be beneficial.