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For reasons of safety as well as cost, increasingly lengthy space missions at unprecedented distances from Earth in the 21st century will require reductions in consumables and increases in the autonomy of spacecraft life support systems. Advanced life support technologies can increase mission productivity and enhance science yield by achieving reductions in the mass, volume, and power required to support human needs for long periods of time in sterile and hostile environments. Current investment in developing advanced life support systems for orbital research facilities will increase the productivity of these relatively near-term missions, while contributing to the technology base necessary for future human exploration missions.