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Testing of regenerative life support systems intended for space applications requires either simulation of the contributions which man makes to system operation or the actual incorporation of humans into the test environment. When man is included in the environment his purpose is often viewed as simply a device to provide a realistic challenge to the systems under test. In actuality, the inclusion of man in a confined environment results in an opportunity for evaluation of both the subsystems under test as well as the humans. Overall test success or failure can be affected by selection and management of both the human and the subsystem elements. Techniques for the selection and management of crew members for long duration confinement in various environments have evolved from those which can be characterized as “skills-determined” to a more sophisticated process based upon psycho social methods.