Technical Paper
Investigation of Diffuse Axonal Injury in Rats Induced by the Combinations of Linear and Rotational Accelerations
2024-04-09
2024-01-2513
Diffuse axonal injury (DAI) is mainly caused by the combination of linear and rotational accelerations resulting from traffic accidents and sports-related incidents, which may lead to disability or death. To quantify the contribution of linear and rotational acceleration to DAI, rat head impact experiments were performed in this paper. A two-factor, two-level experimental protocol for linear acceleration (100G, 300G) and rotational acceleration (110krad/s2, 180krad/s2) was established using the L4(23) orthogonal table. According to the experimental protocol, the combination of linear and rotational accelerations was applied to the rat head. The percentage of axonal injury area in the corpus callosum was taken as the evaluation indicator. The contribution of the factors on the indicator, the differences between the levels of the factors and the influence of errors on the results were quantified by ANOVA.