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This paper describes the validation of RAMSIS, a 3-D CAD human model for ergonomic vehicle evaluation. At GM NAO, the model’s capability to correctly predict position and posture in vehicle CAD environments was tested. H- and Eye point locations between RAMSIS manikins and their human counterparts were compared. At GM/SAAB the model’s postural discomfort predictability was evaluated. Changes in postural discomfort predictions of the RAMSIS manikins were compared to that of the human subjects when they evaluated two different driving buck conditions. We concluded that RAMSIS has good position, posture and postural discomfort prediction capabilities and is a useful CAD ergonomic evaluation and design tool for vehicle interiors.