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In the overall planning of a manned mission to Mars, all the issues related to human involvement are critical. To a certain extent, they dictate the most severe constraints on the mission scenario and spacecraft architecture. Despite this unanimously recognized importance, limited efforts have been devoted up to now to dedicated research activities on human-related aspects, partially neglected w.r.t. more technical areas like orbital dynamics, propulsion, power generation, etc. This paper summarizes the major results of a survey on the human factors of long duration missions performed by Alenia Spazio in the frame of an ESA study, MARSEMSI, whose aim was to identify possible scenarios and related infrastructure requirements for a manned mission to Mars.