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Research indicates that adaptation to a microgravity environment includes physiological changes to the cardiovascular-respiratory, musculoskeletal, and neurosensory systems. Many of these alterations emerge even during space flights of short duration. Therefore, the advancement of manned space flight from Shuttle to Space Station Freedom (SSF) requires development of effective methods for augmenting the ability of humans to maintain functional performance. Thus, it is the goal of NASA to minimize the consequences of microgravity-induced deconditioning to provide optimal in-flight performance (intra- and extra-vehicular activities), suitable return to a pedestrian environment, and nominal physiological postflight recovery for an expeditious return-to-flight physical status.