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The Augustine advisory committee on the future of the U.S. Space Program has recommended that “Space Station Freedom be revamped to emphasize life sciences and human space operations.” An important component of life sciences research involves the housing, care and maintenance of research specimens. Microbial and odor contamination control measures are necessary to ensure that cross contamination between the crew and specimens is controlled and limited. The bioisolation requirements being applied to life sciences specimen handling facilities are more stringent than those applied in the past. This paper examines the designs and operational features which have been used during previous spaceflight missions to contain and control crew and research specimen wastes.