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The MELISSA (Microbial Ecological LIfe Support System Alternative) project has been set up to be a model for the studies on ecological life support systems for long term space missions. The compartmentalisation of the loop, the choice of the micro-organisms and the axenic conditions have been selected in order to simplify the behaviour of this artificial ecosystem and allow a deterministic and engineering approach. In this framework the MELISSA project has now been running since beginning 1989. In this paper we present the general approach of the study, the scientific results obtained on each independent compartment (mass balance, growth kinetics, limitations, compound conversions,..), the tests of toxicity already performed between some compartments and their effect on the growth kinetics. The technical results on instrumentation and control aspects, and the current status of the ESA/ESTEC hardware are also reviewed.

Presently, Europe is faced with the task of implementing the Columbus Space Program. In a stepwise approach the Columbus Initial Orbital Configuration will involve eventually into a European (permanently) Manned Space Infrastructure. Towards this goal, various technological challenges arise for the Environmental Control and Life Support System (ECLSS). Some of these have already been identified and are subject of initial investigations. To regain oxygen from the metabolic process, a physico-chemical chain of CO2-concentration, CO2-cracking and water electrolysis is under development. The present status of the preliminary breadboarding, composed of a steam desorbed solid amine concentrator and a Sabatier reactor will be discussed. The third item in this chain, the electrolyser, is not yet implemented in this breadboarding but is under test, demonstrating the technology for regenerative fuel cell application.