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Four design parameters: conditioned air flow rate, air-conditioning (A/C) outlet location, body vent location and glass properties were studied to evaluate their effects on passenger thermal comfort. By taking all these parameters into account, nine different cases were simulated for the steady-state cooling process in a simplified GM-10 passenger compartment. Three-dimensional air flow and temperature distributions for each case were obtained using VINE3D, which solves a set of partial differential equations governing mass, momentum and energy balance in the passenger compartment. Based on the computed air flow and temperature distributions, passenger thermal comfort was evaluated by Fanger's method. A/C outlet location and total system flow rate are the most important parameters which influence thermal comfort. The location of the exit vents also plays a significant role on rear passenger comfort.