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The Centrifuge Accommodation Module (CAM) will be the home of the fundamental biology research facilities on the International Space Station (ISS). These facilities are being built by the Biological Research Project (BRP), whose goal is to oversee development of a wide variety of habitats and host systems to support life sciences research on the ISS. The habitats and host systems are designed to provide life support for a variety of specimens including cells, bacteria, yeast, plants, fish, rodents, eggs (e.g., quail), and insects. Each habitat contains specimen chambers that allow for easy manipulation of specimens and alteration of sample numbers. All habitats are capable of sustaining life support for 90 days and have automated as well as full telescience capabilities for sending habitat parameters data to investigator homesite laboratories.

The effects of acoustic levels in manned space vehicles was not thoroughly appreciated until the STS 40 mission, Spacelab Life Sciences 1 (June, 1991). Previous to that mission, waivers were submitted and equipment operated without overwhelming effect on ongoing flight activities. The factors of multiple pieces of noise producing equipment operating simultaneously, operating in the vicinity of crew sleep stations, and operating for this long of a mission (10 days) became relevant in crew tolerance, fatigue, communication, and permanent shifts in hearing thresholds. Because this was a life sciences mission, accurate instrument measurements were obtained of acoustic levels in the middeck, flight deck and spacelab during flight and physiological measurements were obtained from the crew members during all phases of the mission. Due to the STS 40 results, a Spacelab/Payloads Acoustics Working Group (SPAWG) was formed post flight to address acceptable acoustic limits.

Spacelab Life Sciences-3 (SLS-3) was scheduled to be the first United States man-tended microgravity flight containing Rhesus monkeys. The goal of this flight as in the five untended Russian COSMOS Bion flights and an earlier American Biosatellite flight, was to understand the biomedical and biological effects of a microgravity environment using the non-human primate as human surrogate. The SLS-3/Rhesus Project and COSMOS Primate-BIOS flights all utilized the rhesus monkey, Macaca mulatta. The ultimate objective of all flights with an animal surrogate has been to evaluate and understand biological mechanisms at both the system and cellular level, thus enabling rational effective countermeasures for future long duration human activity under microgravity conditions and enabling technical application to correction of common human physiological problems within earth's gravity, e.g., muscle strength and reloading, osteoporosis, immune deficiency diseases.

The white rat, Rattus norvegicus has been used extensively in microgravity flights. Initial NASA flight experiments with rats supported the Shuttle Student Involvement Program (SSIP). Hardware to house the rats was called the Animal Enclosure Module (AEM). The AEM for the SSIP, fit into a middeck locker. Potatoes provided water; food bars, glued on the walls, provided nourishment. Waste was absorbed and odor and microbial growth controlled by sandwiched phosphoric acid treated charcoal and filter materials utilizing much of the technology employed in the Rodent Research Animal Holding Facility, a Spacelab piece of equipment. The SSIP AEM potato “watering” system succumbed to mold and had to be replaced by real water contained within plasma bags. A metal enclosure housed the plasma bags between two heavy springs which forced water through animal activated lixits.

The General Purpose Work Station (GPWS) is a laboratory multi-use facility, as demonstrated during the Spacelab Life Sciences 1 (SLS-1) flight. The unit provided particulate containment under varying conditions, served as an effective work space for manipulating live animals, e.g., rats, served as a containment facility for fixatives, and was proposed for use to conduct in-flight maintenance during connector pin repair. The cabinet has a front door large enough to allow installation of a full-size microscope in-flight and is outfitted with a side window to allow delivery of items into the cabinet without exposure to the spacelab atmosphere. Additional support subsystems include inside cabinet mounting, surgical glove fine manipulations capability, and alternating or direct current power supply for experiment equipment, as will be demonstrated during Spacelab J.

This paper discusses the performance of the Research Animal Holding Facility (RAHF) and General Purpose Work Station (GPWS) plus other associated hardware during the recent flight of Spacelab Life Sciences 1 (SLS-1). The RAHF was developed to provide proper housing (food, water, temperature control, lighting and waste management) for up to 24 rodents during flights on the Spacelab. The GPWS was designed to contain particulates and toxic chemicals generated during plant and animal handling and dissection/fixation activities during space flights. A history of the hardware development involved as well as the redesign activities prior to the actual flight are discussed.