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The Environmental Control and Life Support System (ECLSS) on Space Station utilizes the Stand Alone Major Constituent Analyzer (SAMCA) for monitoring major atmospheric constituents from several sampling locations within the station. This paper describes the design of the flight SAMCA instrument and contains: system overview, SAMCA interface description, mechanical description, operational mode summary, and performance capabilities. The SAMCA monitors six major constituents: oxygen, nitrogen, carbon dioxide, hydrogen, water vapor, and methane. In order to monitor these gases the SAMCA uses a permanent-magnet, single-focusing mass spectrometer. This configuration was originally developed for the Skylab metabolic analyzer and most recently used for the Spacelab's Gas Analyzer Mass Spectrometer, GAMS. For the SAMCA application, the mass spectrometer and its support electronics were repackaged to meet Space Station requirements.