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The large variety of adhesive and sealant formulations required to meet the bonding needs of the automotive industry has necessitated the use of many different resins and fillers. Since these additives dominate the wear characteristics exhibited by the adhesives and sealants, they will affect the operation of the application equipment. In previous work, we developed tests to quantify the abrasivity of an adhesive. In this work, we use one of these tests, a flowbench method, to determine the effect that application process conditions have on adhesive abrasivity in an attempt to minimize the wear incurred by application equipment in a production environment. A statistical design of experiments methodology was employed using the inlet flow pressure, initial nozzle orifice diameter, and adhesive temperature as the control variables and the change in the nozzle orifice area as a measure of equipment wear.