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The Connected and Autonomous Vehicles (CAVs) promise huge economic, social and environmental benefits. The autonomous vehicles supposed to be safer than human drivers. However, the advanced systems and complex levels of automation could also bring accidents by tiny faults of hardware or errors of software. To achieve complete safety, a safety case providing guidance on the identification and classification of hazardous events, and the minimization of these risks needs to be developed throughout the entire development lifecycle process of CAVs. A comprehensible and valid safety case has to employ appropriate safety approaches complying with the automotive functional safety requirements in ISO 26262.