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Cybersecurity attacks exploit vulnerabilities related to the increased complexity and connectivity of critical infrastructure systems. This paper investigates the context and use of key security technologies, processes, challenges and use cases for the design of advanced integrated architectures with security, safety, and real-time performance considerations. In such architectures, deterministic Ethernet standards are used as a baseline for system integration in closed embedded systems or open mixed criticality systems. Security-informed safety development processes for integrated architectures are required to prevent catastrophic failures caused by environmental and cyber threats, due to expanding number of security vulnerabilities in complex and increasingly open systems. State-of-art safety/security processes for integrated systems in cross-industry environments are considered and similarities examined, for different types of integrated architectures.