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Passive sensor (HVAC) manikins have been developed to obtain high-resolution measurements of environmental conditions across a representative human body form. These manikins incorporate numerous sensors that measure air velocity, air temperature, radiant heat flux, and relative humidity. The effect of a vehicle’s climate control system on occupant comfort can be characterized from the data collected by an HVAC manikin. Equivalent homogeneous temperature (EHT) is often used as a first step in a cabin comfort analysis, particularly since it reduces a large data set to a single intuitive number. However, the applicability of the EHT for thermal comfort assessment is limited since it does not account for human homeostasis, i.e., that the human body actively counter-balances heat flow with the environment to maintain a constant core temperature. For this reason, a thermo-physiological human model is required to accurately simulate the body’s dynamic response to a changing environment.