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In conjunction with modern engine design and long term reliability needs, the resistance of engine coolants to oxidative stress has become an increasingly important feature. This paper describes the results of a study that evaluated the influence of parameters such as temperature, aeration and catalytic metal interaction on the oxidation stability of engine coolants. Three different test set-ups were used in which the selected conditions put variable weights to the contribution of each parameter. A comparison was made of the oxidation resistance of multiple high quality OEM approved coolant products with different additive technologies. This work is different from previous investigations focusing mainly on the behavior of coolants in single test conditions.