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This paper presents the activities foreseen on the Leonardo Aircraft Division EIS (Entry In Service) 2020 derivative aircraft performed in the frame of the FP7 European research project TOICA (Thermal Overall Integrated Concept of Aircraft). On board air systems for conventional aircraft are fed by the bleed off-take which penalizes the amount of power available to the turbine of jet or turboprop engines. In order to minimize such operating penalties and optimize the energy efficiency of the overall aircraft, it is of major interest to support trade-offs at aircraft level including aircraft systems as early as possible in the development cycle. The study presents the Virtual Integrated Aircraft methodology and associated simulation activities relying on the system simulation platform LMS Imagine.Lab. This methodology is also relying on concept of flexible model and pyramid of models developed in the context of TOICA.