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Glass lifter is a key part of automobile door system. Guide rail is the carrier of glass lifter, and it bears various load cases when glass lifer works. Mass, stiffness and natural frequencies are the factors that influence the performance of glass lifter. In order to design a lighter and reasonable glass lifter, topology optimization methods are studied in this paper. In a rope-wheel glass lifter, design domain is determined by the mechanical structure and working conditions. Firstly, the single target continuum structure topology optimization mathematic models of guide rail are built in this paper, and analysis of multi-stiffness topology optimization are carried out accordingly in which volume fraction is set as 0.4, 0.5 and 0.6. These models are based on SIMP (Solid Isotropic Material with Penalization) theory.