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One main objective is to find out how these parameters interact and optimal driver control gain and driver preview time are obtained. Some steps further, neuromuscular dynamics is considered and the system becomes different from the simplified driver-vehicle system studied before. New optimal driver control gain and driver preview time could be obtained for both tensed and relaxed muscle state. Final step aims at analysing the full system considering driver, neuromuscular, steer-by-wire and vehicle models. The steer-by-wire system could potentially have a significant influence on the vehicle when the driver is at impaired state, which could be represented by setting higher response delay time or smaller preview time. Vehicle's stability and active safety could also be improved by introducing the steer-by-wire system.