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In this paper compatibility studies of biofuel candidates and similar liquids with the elastomeric materials nitrile butadiene rubber and fluoroelastomer are presented. The results gained with defined reference elastomers are compared to results gained with the materials used in the technical application. For this purpose test specimens are prepared from fuel hoses and the material used for shaft seals of fuel pumps. The experimental results are subsequently used to evaluate prediction approaches based on the HSP- and QSPR-method. Finally a comparison of these two approaches is given.