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As lightweight materials and advanced combustion engines are being used in both conventional and electrified vehicles with diverse fuels, it is necessary to evaluate the individual and combined impact of these technologies to reduce energy and greenhouse gas (GHG) emissions. This work uses life cycle assessment (LCA) to evaluate the total energy and GHG emissions for baseline and lightweight internal combustion vehicles (ICVs), hybrid electric vehicles (HEVs) and plug-in hybrid electric vehicles (PHEVs) when they are operated with baseline and advanced gasoline and ethanol engines. Lightweight vehicle models are evaluated with primary body-in-white (BIW) mass reductions using aluminum and advanced/high strength steel (A/HSS) and secondary mass reductions that include powertrain re-sizing. Advanced engine/fuel strategies are included in the vehicle models with fuel economy maps developed from single cylinder engine models.