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Variable nozzle turbine (VNT) adjusts the openings of its nozzles to insure the required flow at throat area, which broadens the operating range of the turbine, and improves the matching relationship between the turbocharger and the engine. But the changes of nozzle openings have significant influence on the flow field structure of downstream radial turbine. To evaluate this effect, the leakage flow through nozzle clearance in various nozzle openings were simulated by unsteady computational fluid dynamic (CFD). Meanwhile, the interaction between nozzle clearance leakage flow and nozzle wake were investigated to reveal its effects on aerodynamic losses and forced responses for downstream rotor. The results showed that the changes of nozzle openings not only affect the interaction between nozzle leakage flows and wake significantly, but also affect aerodynamic performance of the rotor and the blade forced response.