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General comfort may be defined as the “level of well-being” perceived by humans in a working environment. The state-of-the-art about evaluation of comfort/discomfort shows the need for an objective method to evaluate the “effect in the internal body” and “perceived effects” in main systems of comfort perception. In the early phases of automotive design, the seating and dashboard command can be virtually prototyped, and, using Digital Human Modeling (DHM) software, several kinds of interactions can me modeled to evaluate the ergonomics and comfort of designed solutions. Several studies demonstrated that DHM approaches are favorable in virtual reachability and usability tests as well as in macro-ergonomics evaluations, but they appear insufficient in terms of evaluating comfort.