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Ground vehicle subjecting to a blast can sustain vehicle damages and occupant injuries. Direct blast thermal and force loadings compromise vehicle structural integrity and cause damages. Computer simulations of vehicle blast wave damages can be obtained by solving the gas dynamics of the blast wave and the structural dynamics of the vehicle, through a projection of the wave's impact on the vehicle structure. There are various possible ways that the blast can cause injuries to the vehicle occupants, such as direct collision with objects instantly accelerated by the blast pressure and impact by the secondary shock waves transmitted through the platform structure. This paper describes a parallel computer simulation methodology that can potentially be applied to predict the structure damage and the associated occupant kinematics during a blast event by solving the multi-physics problem of fluid dynamics, solid dynamics, and multi-body dynamics.