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In response to more stringent greenhouse gas and fuel economy standards and increasing consumer demand for fuel efficient vehicles, automobile manufacturers have identified vehicle mass reduction as a leading strategy for reducing greenhouse gas emissions and improving fuel economy. The potential for significant levels of mass reduction can only be understood using a full-vehicle analysis, partly because mass reduction in one vehicle system or part can enable additional reductions elsewhere. This paper describes a holistic approach in which the most cost-effective mass reduction ideas were selected using a structured optimization procedure, and the crash safety of the resultant design was evaluated using a full-vehicle engineering analysis.