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Regulatory crash tests provide minimum performance standards for the safety of vehicles sold in the United States. In order to evaluate the similarity of real world crashes to crash tests, a method was developed to compare Crash Injury Research and Engineering Network (CIREN) crashes to crash tests for frontal and side impacts in a controlled, repeatable approach. The purpose of developing a new methodology was to enable future in-depth research on occupant injuries. Three parameter sets were compared for similarities: crash, vehicle, and occupant characteristics. Occupant injuries were compared with injury probabilities calculated from Anthropomorphic Test Devices (ATD). Two vehicle parameters, six crash parameters, and five occupant parameters were developed as comparison criteria while additional parameters were included only as supplemental information. CIREN contained in-depth crash and occupant injury information to make crash outcome comparisons possible.