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The Aircraft System Health Management (ASHM) tool is a UTC developed web application that provides access to Aircraft Condition Monitoring Function (ACMF) reports and Flight Deck Effects (FDE) records for Boeing 787®, A320®, and A380® aircraft. The tool was built with a flexible architecture to field a range of off-board diagnostics and prognostics modules designed to transform an abundance of data into actionable and timely knowledge about fleet health. This paper describes the system architecture and implementation with a focus on “lessons learned” in applying diagnostic and prognostics algorithms to available fleet data. Key topics include ensuring analytic robustness, design for cross-enterprise collaboration and defining a workable approach to testing, validating and deploying prognostics and diagnostics models with various degrees of complexity. A case study is provided related to fluid leak detection within an environmental control subsystem.