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In amorphous solids such as fused quartz, the failure mechanism under cyclic loading is very different when compared to metals where this failure is attributable to dislocation movement and eventual slip band activity. Standard mechanical fatigue prediction methodologies, S-N or ε-N based, which have been historically developed for metals are rendered inapplicable for this class of material. The fatigue strength of Fused Silica or Fused Quartz (SiO2) material is known to be highly dependent on the stressed area and the surface finish. Stable crack growth in Region II of the V-K curve (Crack growth rate vs Stress intensity factor) is dependent on the competing and transitional effects of temperature and humidity, along that specific section of the stress intensity factor abscissa. Fused glass (under harsh environment conditions) finds usage in Automotive, Marine and Aerospace applications, where stress and load (both static and cyclic) can be severe.