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Computational analysis of occupant safety has become an efficient tool to reduce the development time for a new product. Multi-body computer models (e.g. Madymo models) that simulate vehicle interior, restraint system and occupants in various crash modes have been widely used in the occupant safety area. To ensure public safety, many injury numbers, such as head injury criteria, chest acceleration, chest deflection, femur loads, neck load, and neck moment, are monitored. Deterministic optimization methods have been employed to meet various safety requirements. However, with the further emphasis on product quality and consistency of product performance, variations in modeling, simulation, and manufacturing, need to be considered.